A seaport on the northwest coast of Italy, Genoa is the birthplace of Christopher Columbus (or so many academics claim). Its landmarks include the early 13th-century Cathedral of San Lorenzo, with a pretty black-and-white striped façade, and an ancient lighthouse near the port. Visit one of the many art galleries housing impressive collections, or for a change of pace, see the exhibits at the Genoa Aquarium, one of the largest in Europe.